Work Package 2

GENERATION OF RELEVANT CELLULAR MODELS OF CSDs AND RSDs

 

Work package leader:

Anna Villa (CNR)

 

Objectives:

  • To establish a range of cellular models of RSDs and CSDs using both physiological and surrogate cell lines.
  • To establish primary cell lines from patients and animal models (zebrafish and mouse) carrying different genetic variations.
  • To generate iPS cell lines from human cells (e.g. urine & blood cells or skin fibroblasts) of RSD patients.
  • To obtain differentiated cells from iPS and mES cells.

 

Partners involved in WP2: