Work Package 1

PRIORITISATION OF DISEASE-CAUSING GENETIC VARIANTS FOR FUNCTIONAL VALIDATION

Work package leaders:

Geert Mortier (UA) and Laurence Legeai-Mallet (INSERM)

Objectives:

• To catalogue all genetic variants currently studied by SYBIL partners.
• To select genetic variants for functional validation in cellular and animal models.
• To prioritise for functional validation of new genetic variants identified during the first 3 years of the project.

Partners involved in WP1:

• Newcastle University
• University of L’Aquila
• University of Manchester
• Alacris Theranostics
• University of Pavia
• Consiglio Nazionale delle Ricerche
• Institut National de la Santé et de la Recherche Médicale
• Certus Technology Associates Limited
• Charité – Universitaetsmedizin Berlin
• University Medical Center Hamburg Eppendorf
• University Hospital of Cologne
• University of Freiburg
• University of Antwerp